Recent Publications
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The Effect of Marrow Secretome and Culture Environment on the Rate of
Metastatic Breast Cancer Cell Migration in Two and Three Dimensions.
Curtis KJ, Mai C, Martin H, Oberman AG, Alderfer L, Romero-Moreno R,
Walsh M, Mitros SF, Thomas SG, Dynako JA, Zimmer DI, McNamara LM,
Littlepage LE, Niebur GL.
2021;
Mol Biol Cell. 2021 Mar 10:mbcE19120682.
doi: 10.1091/mbc.E19-12-0682
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Mechanical stimuli and matrix properties modulate cancer spheroid
growth in three-dimensional gelatin culture
Curtis Kimberly J., Schiavi Jessica, Mc Garrigle Myles J., Kumar Vatsal,
McNamara Laoise M. and Niebur Glen L.
2020;J. R. Soc. Interface.1720200568
doi: 10.1098/rsif.2020.0568
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The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization
during bone metastasis.
Romero-Moreno R, Curtis KJ, Coughlin TR, Cristina Miranda-Vergara M,
Dutta S, Natarajan A, Facchine BA, Jackson KM, Nystrom L, Li J,
Kaliney W, Niebur GL, Littlepage LE.
Nat Commun. 2019 Sep 27;10(1):4404. doi: 10.1038/s41467-019-12108-6.
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Effects of mechanobiological signaling in bone marrow on skeletal health.
Curtis KJ, Oberman AG, Niebur GL.
Ann N Y Acad Sci. 2019 Sep 11. doi: 10.1111/nyas.14232. Review.
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Potassium channel activity controls breast cancer metastasis by
affecting β-catenin signaling.
Breuer EK, Fukushiro-Lopes D, Dalheim A, Burnette M, Zartman J, Kaja S,
Wells C, Campo L, Curtis KJ, Romero-Moreno R, Littlepage LE,
Niebur GL, Hoskins K, Nishimura MI, Gentile S.
Cell Death Dis. 2019 Feb 21;10(3):180. doi: 10.1038/s41419-019-1429-0.
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Shear Stress in Bone Marrow has a Dose Dependent Effect on cFos Gene
Expression in In Situ Culture.
Kimberly J Curtis, Thomas R Coughlin, Mary A Varsanik, Glen L Niebur
Cell Mol Bioeng. 2019 Aug 27;12(6):559-568. doi: 10.1007/s12195-019-00594-z
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Bone marrow mechanotransduction in porcine explants alters kinase
activation and enhances trabecular bone formation in the absence of
osteocyte signaling.
Curtis KJ, Coughlin TR, Mason DE, Boerckel JD, Niebur GL.
Bone. 2018 Feb;107:78-87. doi: 10.1016/j.bone.2017.11.007.
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Mechanically induced bone formation is not sensitive to local osteocyte
density in rat vertebral cancellous bone.
Cresswell EN, Nguyen TM, Horsfield MW, Alepuz AJ, Metzger TA, Niebur GL,
Hernandez CJ.
J Orthop Res. 2018 Feb;36(2):672-681. doi: 10.1002/jor.23606.
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Intraoperative biomechanics of lumbar pedicle screw loosening following
successful arthrodesis.
Pearson HB, Dobbs CJ, Grantham E, Niebur GL, Chappuis JL, Boerckel JD.
J Orthop Res. 2017 Dec;35(12):2673-2681. doi: 10.1002/jor.23575.
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Three-dimensional printing of X-ray computed tomography datasets with
multiple materials using open-source data processing.
Sander IM, McGoldrick MT, Helms MN, Betts A, van Avermaete A, Owers E,
Doney E, Liepert T, Niebur G, Liepert D, Leevy WM.
Anat Sci Educ. 2017 Jul;10(4):383-391. doi: 10.1002/ase.1682.
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Anisotropic Permeability of Trabecular Bone and its Relationship to
Fabric and Architecture: A Computational Study.
Kreipke TC, Niebur GL.
Ann Biomed Eng. 2017 Jun;45(6):1543-1554. doi: 10.1007/s10439-017-1805-9.
Erratum in: Ann Biomed Eng. 2017 Jun;45(6):1555-1559.
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Bone: A Fertile Soil for Cancer Metastasis.
Coughlin TR, Romero-Moreno R, Mason DE, Nystrom L, Boerckel JD, Niebur G,
Littlepage LE.
Curr Drug Targets. 2017;18(11):1281-1295.
doi: 10.2174/1389450117666161226121650. Review.
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Altered architecture and cell populations affect bone marrow
mechanobiology in the osteoporotic human femur.
Metzger TA, Vaughan TJ, McNamara LM, Niebur GL.
Biomech Model Mechanobiol. 2017 Jun;16(3):841-850.
doi: 10.1007/s10237-016-0856-4.
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Comparison of solid and fluid constitutive models of bone marrow during
trabecular bone compression.
Metzger TA, Niebur GL.
J Biomech. 2016 Oct 3;49(14):3596-3601. doi: 10.1016/j.jbiomech.2016.09.018.
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The roles of architecture and estrogen depletion in microdamage risk in
trabecular bone.
Kreipke TC, Garrison JG, Easley J, Turner AS, Niebur GL.
J Biomech. 2016 Oct 3;49(14):3223-3229. doi: 10.1016/j.jbiomech.2016.08.009.
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Primary cilia expression in bone marrow in response to mechanical
stimulation in explant bioreactor culture.
Coughlin TR, Schiavi J, Alyssa Varsanik M, Voisin M, Birmingham E, Haugh MG, McNamara LM, Niebur GL.
Eur Cell Mater. 2016 Jul 19;32:111-22.
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Pressure and shear stress in trabecular bone marrow during whole bone loading.
Metzger TA, Schwaner SA, LaNeve AJ, Kreipke TC, Niebur GL.
J Biomech. 2015 Sep 18;48(12):3035-43. doi: 10.1016/j.jbiomech.2015.07.028.
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An Experimental and Computational Investigation of Bone Formation in
Mechanically Loaded Trabecular Bone Explants.
Birmingham E, Niebur GL, McNamara LM, McHugh PE.
Ann Biomed Eng. 2016 Apr;44(4):1191-203. doi: 10.1007/s10439-015-1378-4.
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The sensitivity of nonlinear computational models of trabecular bone to
tissue level constitutive model.
Baumann AP, Shi X, Roeder RK, Niebur GL.
Comput Methods Biomech Biomed Engin. 2016;19(5):465-73. doi: 10.1080/10255842.2015.1041022.
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Development of an in vivo rabbit ulnar loading model.
Baumann AP, Aref MW, Turnbull TL, Robling AG, Niebur GL, Allen MR, Roeder RK.
Bone. 2015 Jun;75:55-61. doi: 10.1016/j.bone.2015.01.022.
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Hydroxyapatite reinforced collagen scaffolds with improved architecture
and mechanical properties.
Kane RJ, Weiss-Bilka HE, Meagher MJ, Liu Y, Gargac JA, Niebur GL,
Wagner DR, Roeder RK.
Acta Biomater. 2015 Apr;17:16-25. doi: 10.1016/j.actbio.2015.01.031.
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Primary cilia exist in a small fraction of cells in trabecular bone and marrow.
Coughlin TR, Voisin M, Schaffler MB, Niebur GL, McNamara LM.
Calcif Tissue Int. 2015 Jan;96(1):65-72. doi: 10.1007/s00223-014-9928-6.
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The in situ mechanics of trabecular bone marrow: the potential for
mechanobiological response.
Metzger TA, Kreipke TC, Vaughan TJ, McNamara LM, Niebur GL.
J Biomech Eng. 2015 Jan;137(1). doi: 10.1115/1.4028985.
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Multiscale modeling of trabecular bone marrow: understanding the
micromechanical environment of mesenchymal stem cells during osteoporosis.
Vaughan TJ, Voisin M, Niebur GL, McNamara LM.
J Biomech Eng. 2015 Jan;137(1). doi: 10.1115/1.4028986.
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Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants.
Birmingham E, Kreipke TC, Dolan EB, Coughlin TR, Owens P, McNamara LM,
Niebur GL, McHugh PE.
Ann Biomed Eng. 2015 Apr;43(4):1036-50. doi: 10.1007/s10439-014-1135-0.
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Rheological behavior of fresh bone marrow and the effects of storage.
Metzger TA, Shudick JM, Seekell R, Zhu Y, Niebur GL.
J Mech Behav Biomed Mater. 2014 Dec;40:307-313.
doi: 10.1016/j.jmbbm.2014.09.008.
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Characterization of cancellous and cortical bone strain in the in vivo mouse
tibial loading model using microCT-based finite element analysis.
Yang H, Butz KD, Duffy D, Niebur GL, Nauman EA, Main RP.
Bone. 2014 Sep;66:131-9. doi: 10.1016/j.bone.2014.05.019.
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Alterations in trabecular bone microarchitecture in the ovine spine and distal femur following ovariectomy.
Kreipke TC, Rivera NC, Garrison JG, Easley JT, Turner AS, Niebur GL.
J Biomech. 2014 Jun 3;47(8):1918-21.
doi: 10.1016/j.jbiomech.2014.03.025.
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A probabilistic damage model based on direct 3-D correlation of strain to
damage formation following fatigue loading of rat femora.
Gargac JA, Turnbull TL, Roeder RK, Niebur GL.
J Mech Behav Biomed Mater. 2014 Feb;30:234-43.
doi: 10.1016/j.jmbbm.2013.11.009.
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